dc.contributor.author | Yalçın, Ergin | |
dc.contributor.author | Erkmen, Cem | |
dc.contributor.author | Tok, Tuğba Taşkın | |
dc.contributor.author | Çağlayan, Mehmet Gökhan | |
dc.date.accessioned | 2020-05-24T14:24:13Z | |
dc.date.available | 2020-05-24T14:24:13Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Yalcin, E., Erkmen, C., Taskin-Tok, T., Caglayan, M. G., (2020). Fluorescence chemosensing of meldonium using a cross-reactive sensor array. The Analyst, 145(9), 3345–3352. https://doi.org/10.1039/d0an00209g | en_US |
dc.identifier.issn | 0003-2654 | |
dc.identifier.uri | https://doi.org/10.1039/d0an00209g | |
dc.identifier.uri | https://hdl.handle.net/20.500.12508/1039 | |
dc.description.abstract | In this paper, we report a fluorescent sensor array approach for the urinary detection of a prohibited substance in sports, meldonium. Four chemosensors with ethidium bromide scaffolds were employed in this method. The interaction between meldonium and chemosensors was investigated by different techniques, such as ultraviolet-visible absorption and fluorescence spectroscopy, nuclear magnetic resonance, and mass spectrometry. Molecular dynamics simulation was also used to elucidate and support the interaction mechanisms between meldonium and the chemosensors. Differential responses obtained from the sensor array enabled the qualitative and quantitative analyses of meldonium with low error values. This method was able to detect and quantify meldonium at the nM level, fulfilling the requirements of minimum performance defined by the World Anti-Doping Agency. © The Royal Society of Chemistry 2020. | en_US |
dc.description.sponsorship | 117Z185 Türkiye Bilimsel ve Teknolojik Araştırma Kurumu | en_US |
dc.description.sponsorship | The authors acknowledge the Scientific and Technological Research Council of Turkey (TUBITAK, project no.: 117Z185) for financial support. The authors also specially thank Dr Yesim Somay Selbes from the Turkish Doping Control Center and Prof. Dr Zeynel Seferoglu from Gazi University for their support. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.relation.isversionof | 10.1039/d0an00209g | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject.classification | Chemistry | en_US |
dc.subject.classification | Analytical | en_US |
dc.subject.classification | Carnitine | Fatty Acids | Metabolism | en_US |
dc.subject.other | Human plasma | en_US |
dc.subject.other | Human urine | en_US |
dc.subject.other | Mildronate | en_US |
dc.subject.other | Absorption spectroscopy | en_US |
dc.subject.other | Fluorescence spectroscopy | en_US |
dc.subject.other | Mass spectrometry | en_US |
dc.subject.other | Molecular dynamics | en_US |
dc.subject.other | Nuclear magnetic resonance spectroscopy | en_US |
dc.subject.other | Scaffolds | en_US |
dc.subject.other | Differential response | en_US |
dc.subject.other | Ethidium bromide | en_US |
dc.subject.other | Fluorescent sensors | en_US |
dc.subject.other | Interaction mechanisms | en_US |
dc.subject.other | Molecular dynamics simulations | en_US |
dc.subject.other | Qualitative and quantitative analysis | en_US |
dc.subject.other | Ultraviolet visible absorption | en_US |
dc.subject.other | World Anti-Doping Agency | en_US |
dc.title | Fluorescence chemosensing of meldonium using a cross-reactive sensor array | en_US |
dc.type | article | en_US |
dc.relation.journal | The Analyst | en_US |
dc.contributor.department | Mühendislik ve Doğa Bilimleri Fakültesi -- Mühendislik Temel Bilimleri Bölümü | en_US |
dc.identifier.volume | 145 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 3345 | en_US |
dc.identifier.endpage | 3352 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.contributor.isteauthor | Yalçın, Ergin | en_US |
dc.relation.index | Web of Science - Scopus - PubMed | en_US |
dc.relation.index | Web of Science Core Collection - Science Citation Index Expanded | en_US |