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dc.contributor.authorMedetalibeyoğlu, Hilal
dc.contributor.authorBeytur, Murat
dc.contributor.authorAkyıldırım, Onur
dc.contributor.authorAtar, Necip
dc.contributor.authorYola, Mehmet Lütfi
dc.date.accessioned2020-12-03T10:07:51Z
dc.date.available2020-12-03T10:07:51Z
dc.date.issued2020en_US
dc.identifier.citationMedetalibeyoglu, H., Beytur, M., Akyıldırım, O., Atar, N., Yola, M.L. (2020). Validated electrochemical immunosensor for ultra-sensitive procalcitonin detection: Carbon electrode modified with gold nanoparticles functionalized sulfur doped MXene as sensor platform and carboxylated graphitic carbon nitride as signal amplification. Sensors and Actuators, B: Chemical, 319, art. no. 128195. https://doi.org/10.1016/j.snb.2020.128195en_US
dc.identifier.urihttps://doi.org/10.1016/j.snb.2020.128195
dc.identifier.urihttps://hdl.handle.net/20.500.12508/1440
dc.description.abstractSepticemia, also known as sepsis, refers to a systemic inflammatory response syndrome and becomes thedominant reason of mortality for seriously diseases. Procalcitonin (PCT), the peptide precursor of the hormones,is a key biomarker of septicemia in the diagnosis and detection of bacterial inflammation. In this study, an ultra-sensitive sandwich type electrochemical immunosensor for PCT detection was constructed. Firstly, delaminatedsulfur-doped MXene (d-S-Ti3C2TXMXene) modified glassy carbon electrode (GCE) including gold nanoparticles(AuNPs) was utilized as immunosensor platform to increase the amount of PCT antibody1 (Ab1). After that,carboxylated graphitic carbon nitride (c-g-C3N4) was used to label PCT Ab2as signal amplification. The structureof electrochemical immunosensor was highlighted by x-ray diffraction (XRD) method, scanning electron mi-croscope (SEM), transmission electron microscopy (TEM), x-ray photoelectron spectroscopy (XPS), fouriertransform infrared spectroscopy (FTIR), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry(CV). Herein, c-g-C3N4not only has excellent catalytic activity toward H2O2for signal amplification, but also canbe directly utilized as redox probe. The analytical results have revealed that 0.01 - 1.0 pg mL-1and 2.0 fg mL-1were found as linearity range and limit of detection (LOD). Furthermore, the validated electrochemical im-munosensor was examined in terms of stability, repeatability, reproducibility and reusability. Finally, the im-munosensor was applied to plasma samples having high recoveryen_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.snb.2020.128195en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProcalcitoninen_US
dc.subjectSulfur-doped MXeneen_US
dc.subjectCarboxylated graphitic carbon nitrideen_US
dc.subjectImmunosensoren_US
dc.subjectValidationen_US
dc.subject.classificationChemistry
dc.subject.classificationAnalytical
dc.subject.classificationElectrochemistry
dc.subject.classificationInstruments & Instrumentation
dc.subject.classificationImmunosensors | Carcinoembryonic Antigen | Alpha Fetoprotein
dc.subject.otherUltrasensitive detection
dc.subject.otherSepsis diagnosis
dc.subject.otherGraphene
dc.subject.otherPerformance
dc.subject.otherNanocomposites
dc.subject.otherg-c3n4
dc.subject.otherNanosheets
dc.subject.otherFilm
dc.subject.otherCatalyst activity
dc.subject.otherCyclic voltammetry
dc.subject.otherDiagnosis
dc.subject.otherElectrochemical impedance spectroscopy
dc.subject.otherFiber optic sensors
dc.subject.otherFourier transform infrared spectroscopy
dc.subject.otherGlass membrane electrodes
dc.subject.otherGold nanoparticles
dc.subject.otherHigh resolution transmission electron microscopy
dc.subject.otherImmunosensors
dc.subject.otherMetal nanoparticles
dc.subject.otherReusability
dc.subject.otherScanning electron microscopy
dc.subject.otherX ray photoelectron spectroscopy
dc.subject.otherAnalytical results
dc.subject.otherElectrochemical immunosensors
dc.subject.otherLimit of detection
dc.subject.otherModified glassy carbon electrode
dc.subject.otherReproducibilities
dc.subject.otherSignal amplifications
dc.subject.otherSystemic inflammatory response syndromes
dc.subject.otherUltra sensitives
dc.subject.otherAmplification
dc.titleValidated electrochemical immunosensor for ultra-sensitive procalcitonin detection: Carbon electrode modified with gold nanoparticles functionalized sulfur doped MXene as sensor platform and carboxylated graphitic carbon nitride as signal amplificationen_US
dc.typearticleen_US
dc.relation.journalSensors and Actuators, B: Chemicalen_US
dc.contributor.departmentMühendislik ve Doğa Bilimleri Fakültesi -- Biyomedikal Mühendisliği Bölümüen_US
dc.identifier.volume319en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.isteauthorYola, Mehmet Lütfi
dc.relation.indexWeb of Science - Scopusen_US
dc.relation.indexWeb of Science Core Collection - Science Citation Index Expanded


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