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dc.contributor.authorYalçın, Ergin
dc.date.accessioned2021-12-30T10:33:42Z
dc.date.available2021-12-30T10:33:42Z
dc.date.issued2021en_US
dc.identifier.citationYalçın, E. (2021). Synthesis of novel fused acenaphtopyrimidine hybrid, its photophysical properties and HSA interaction. Supramolecular Chemistry. https://doi.org/10.1080/10610278.2021.1975710en_US
dc.identifier.urihttps://doi.org/10.1080/10610278.2021.1975710
dc.identifier.urihttps://hdl.handle.net/20.500.12508/2028
dc.description.abstractA facile and versatile procedure for the synthesis of novel functionalised 10-(1H-indol-3-yl)acenaphtho[1,2-d]pyrimidin-8-amine (compound 4) has been described. The novel intermediate enone (3) and pyrimidine derivatives (4) were characterised by using FT-IR, NMR and MS. Moreover, the photophysical properties of compound 4 and its interaction with HSA (Human Serum Albumin) have been investigated by means of photometric and fluorimetric titration. Compound 4 showed the increase in fluorescence and hypsochromic shift of its maximum upon the addition of HSA that interaction is supported by molecular docking. Overall, Compound 4 has promising affinity towards HSA which was not previously reported for any fused acenaphtenone-pyrimidine hybrid analogues.en_US
dc.language.isoengen_US
dc.publisherTaylor and Francisen_US
dc.relation.isversionof10.1080/10610278.2021.1975710en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcenaphtopyrimidine derivativesen_US
dc.subjectFused heterocyclic compoundsen_US
dc.subjectHSA interactionen_US
dc.subjectPhotophysical propertiesen_US
dc.subjectSolvatochromismen_US
dc.subject.classificationChemistry
dc.subject.classificationHuman Serum Albumin
dc.subject.classificationVan Der Waals Forces
dc.subject.classificationPepsin A
dc.subject.otherHuman serum-albumin
dc.subject.otherDna/Hsa-binding
dc.subject.otherSolvatochromism
dc.titleSynthesis of novel fused acenaphtopyrimidine hybrid, its photophysical properties and HSA interactionen_US
dc.typearticleen_US
dc.relation.journalSupramolecular Chemistryen_US
dc.contributor.departmentMühendislik ve Doğa Bilimleri Fakültesi -- Mühendislik Temel Bilimleri Bölümüen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.isteauthorYalçın, Ergin
dc.relation.indexWeb of Science - Scopusen_US
dc.relation.indexWeb of Science Core Collection - Science Citation Index Expanded


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