dc.contributor.author | Yalçın, Ergin | |
dc.date.accessioned | 2021-12-30T10:33:42Z | |
dc.date.available | 2021-12-30T10:33:42Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Yalçın, E. (2021). Synthesis of novel fused acenaphtopyrimidine hybrid, its photophysical properties and HSA
interaction. Supramolecular Chemistry.
https://doi.org/10.1080/10610278.2021.1975710 | en_US |
dc.identifier.uri | https://doi.org/10.1080/10610278.2021.1975710 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12508/2028 | |
dc.description.abstract | A facile and versatile procedure for the synthesis of novel functionalised 10-(1H-indol-3-yl)acenaphtho[1,2-d]pyrimidin-8-amine (compound 4) has been described. The novel intermediate enone (3) and pyrimidine derivatives (4) were characterised by using FT-IR, NMR and MS. Moreover, the photophysical properties of compound 4 and its interaction with HSA (Human Serum Albumin) have been investigated by means of photometric and fluorimetric titration. Compound 4 showed the increase in fluorescence and hypsochromic shift of its maximum upon the addition of HSA that interaction is supported by molecular docking. Overall, Compound 4 has promising affinity towards HSA which was not previously reported for any fused acenaphtenone-pyrimidine hybrid analogues. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor and Francis | en_US |
dc.relation.isversionof | 10.1080/10610278.2021.1975710 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Acenaphtopyrimidine derivatives | en_US |
dc.subject | Fused heterocyclic compounds | en_US |
dc.subject | HSA interaction | en_US |
dc.subject | Photophysical properties | en_US |
dc.subject | Solvatochromism | en_US |
dc.subject.classification | Chemistry | |
dc.subject.classification | Human Serum Albumin | |
dc.subject.classification | Van Der Waals Forces | |
dc.subject.classification | Pepsin A | |
dc.subject.other | Human serum-albumin | |
dc.subject.other | Dna/Hsa-binding | |
dc.subject.other | Solvatochromism | |
dc.title | Synthesis of novel fused acenaphtopyrimidine hybrid, its photophysical properties and HSA interaction | en_US |
dc.type | article | en_US |
dc.relation.journal | Supramolecular Chemistry | en_US |
dc.contributor.department | Mühendislik ve Doğa Bilimleri Fakültesi -- Mühendislik Temel Bilimleri Bölümü | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.contributor.isteauthor | Yalçın, Ergin | |
dc.relation.index | Web of Science - Scopus | en_US |
dc.relation.index | Web of Science Core Collection - Science Citation Index Expanded | |